APIS Target Triage (ATTTM)
APIS Target Triage (ATTTM) is an innovative service that has been meticulously packaged as a product with a clear mission: to validate drug or biomarker targets effectively. By combining advanced AI tools (LLMs, ML models) with automated workflows, it empowers researchers to:
Find high-confidence targets faster
Reduce research costs
Improve experimental success rates
Accelerate the path from discovery to preclinical studies
ATT Features
-
Comprehensive review and extraction of targets and related information from:
scientific publications
databases,
data & knowledge repositories
Rapid extraction and analysis from millions of scientific articles and datasets using LLMs.
-
Evaluates potential targets using various biological and clinical parameters. Assesses target relevance through:
Disease Association
Expression & Pathway Analysis
Safety Inspection
Validation of Existing Studies, Cohorts & Drug Experiments
-
Provides interactive tools to visualise target data.
Allows users to filter, prioritise, and explore targets based on customisable parameters, improving decision-making and discovery workflows.
-
Assesses the potential binding interactions between targets and drug candidates.
Helps in ranking targets based on their likelihood to engage with specific molecules or therapeutic compounds.
Utilises advanced machine learning approaches to predict binding affinities, analyse molecular docking results, and identify potential off-target effects, improving accuracy and reducing false positives
-
Generates comprehensive, data-driven reports and summaries.
Offers insights and actionable recommendations to guide research, development, and decision-making processes.
Uses LLMs (Large Language Models) to generate concise summaries, highlight key insights, and assist in interactive result exploration.
Accelerated Target Discovery and Validation
Automated Data Mining: Rapid extraction and analysis from millions of scientific articles and datasets using LLMs
Faster Target Prioritization: Efficient filtering of >2.4 million candidates through automated scoring and ranking mechanisms
Quick Iterations: Reduces time from data collection to actionable insights
Benefits of ATT
Data-Driven Decision Making
Interactive Visualization & Smart Reports: Provides clear summaries and actionable recommendations using LLMs
Protein Target Profiling: Evaluates key protein attributes such as tissue specificity, RNA expression levels (TPM), and blood concentration
Machine Learning Predictions: Uses models for binding affinity predictions and supporting informed go/no-go decisions
Cost-Effective Research Operations
Reduces Wet-Lab Failures: Focuses only on high-confidence targets before experimental validation
Minimises Trial-and-Error: Computational modeling identifies potential failures early
Optimised Resource Allocation: Saves time and budget by prioritising the most promising candidates for laboratory testing
Scalable and Reproducible Process
End-to-End Automation: Reduces manual effort and human error in the discovery pipeline
Consistent Output: Standardises validation steps, ensuring reproducibility across projects
Customisable Workflow: Adjusts filtering criteria based on customer-specific inputs (e.g., disease area, mechanism of action)
How does ATT work?
ATT aims to accelerate the selection process and provide confidence in level of evidence of disease target association, prior to commencing wet-work
LLMs
Fast literature analysis, better insights.
Reduces manual effort in literature reviews and ensures no critical information is missed.
Performs natural language queries to answer complex research questions.
Technological Backbone
AI/ML Models
Accurate predictions and fewer false positives.
Assesses molecular docking results to predict interactions between drugs and targets.
Cloud Computing
Scalable, high-speed data processing.
Scales dynamically to handle large workloads.
Stores and retrieves large datasets efficiently.
Multi-Omics Integration
Holistic view of target relevance.
Combines data from genomics, transcriptomics, proteomics, and clinical studies.
Provides a comprehensive biological profile for each target.
Ordering Information
| Product | Catalogue Number | Price |
|---|---|---|
| APIS Target Triage (ATT) | 02601 | Available upon request |
To order the APIS Target Triage (ATT) or to learn more about how we can elevate your bioinformatics capabilities, please contact us below.