The Apis Team will be exhibiting and speaking at the online & on-demand Festival of Genomics & Biodata 2022

Be sure not to miss Apis’ Aleksandar Mihajlović (Head of Operations – Bioinformatics, AI/ML & Software Development) and Digenomix’s Dr Larry Xi (CEO & Co-founder) talking on ‘High Resolution CNV Calling in Single Cell NGS-based Diagnostic Assays’ on Wednesday 26th January @ 16.00 – 16.30 (UK) Registration link

Abstract

Single-cell sequencing provides for a new level of granularity in studying the heterogeneous nature of cancer cells. For some cancers, this heterogeneity is the result of copy number changes of genes within the cellular genomes. The ability to accurately determine such copy number changes is critical in tracing and understanding tumorigenesis.

Current single-cell genome sequencing methodologies infer copy numbers based on statistical approaches, followed by rounding decimal numbers to integer values. Such methodologies are sample dependent, have varying calling sensitivities which heavily depend on the sample’s ploidy and are sensitive to noise in sequencing data.

In this talk we will demonstrate the concept on integer-counting, by using a novel bioinformatic algorithm built on novel and proprietary library construction chemistry in order to detect the discrete nature of the genome.

Interested in learning more? Use this link to contact us and schedule a meeting.